Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndromes Risk Assessment Calculator

Based on Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndromes. Greenberg PL, Tuechler H, Schanz J et al. 2012 Blood 120: 2454-2465.

Please fill the variables based in the references in brackets

 

Cytogenetic Category

  • Very Good
  • Good
  • Intermediate
  • Poor
  • Very Poor

 

If you want to adjust the IPSS-R for age (IPSS-RA), enter the patient's age. Otherwise leave the age box empty.

 

 

 

 

X
IPSS-R Cytogenetic risk groups
Cytogenetic prognostic subgroups Cytogenetic abnormalities
Very good -Y, del(11q)
Good Normal, del(5q), del(12p), del(20q), double including del(5q)
Intermediate del(7q), +8, +19, i(17q), any other single or double independent clones
Poor -7, inv(3)/t(3q)/del(3q), double including -7/del(7q), Complex: 3 abnormalities
Very poor Complex: >3 abnormalities

How this calculator works:

Based on Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndromes. Greenberg PL, Tuechler H, Schanz J et al. 2012 Blood 120: 2454-2465.

 

The IPSS-R SCORE is calculated from the data shown in the following table:
IPSS-R Prognostic Score Values
Prognostic variable 0 0.5 1 1.5 2 3 4
Cytogenetics Very Good Good Intermediate Poor Very Poor
BM Blast % <=2 >2-<5% 5-10% >10%
Haemoglobin =>100 80-<100 <80
Platelets =>100 50-<100 <50
ANC =>0.8 <0.8

 

The IPSS-R category determines patient Survival (based on Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndromes. Greenberg PL, Tuechler H, Schanz J et al. 2012 Blood 120: 2454-2465.):
IPSS-R Prognostic Risk Categories/Scores and Clinical Outcomes
RISK CATEGORY RISK SCORE SURVIVAL
(median - years)
25% AML
evolution
(median - years)
Very Low <=1.5 8.8 NR
Low >1.5 - 3 5.3 10.8
Intermediate >3 - 4.5 3.0 3.2
High >4.5 - 6 1.6 1.4
Very High >6 0.8 0.73
 
The survival estimation calculation of risk (IPSS-RA) it is done base on the folowing formula:

result = score + ((age - 70) * (0.05 - (score * 0.005)));
result = result.toFixed(2); (2 decimal values)

 

IPSS-R MDS Risk Assessment Calculator

Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndromes Risk Assessment Calculator

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MDS Fact Sheet

MDS Factsheet for GPs General Practicioners

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Varicella Vaccine in MDS

Urgent Clarification on varicella vaccine policy

Current advice from the UK MDS Forum is not to give the Live Varicella Vaccine to patients with MDS.

Please read below correspondence between Professor Salisbury and Dr George Follows, the latter on behalf of the CLL Forum, on the varicella vaccine policy.
This is an external link to the British Society for Haematology  Click here

NICE Guideline

Lenalidomide for treating myelodysplastic syndromes (MDS) associated with an isolated deletion 5q cytogenetic abnormality.

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BCSH Guideline

This is an external  link to the home of the British Society for Haematology (BSH). 

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Click here