Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndromes Risk Assessment Calculator
Based on Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndromes. Greenberg PL, Tuechler H, Schanz J et al. 2012 Blood 120: 2454-2465.
IPSS-R Cytogenetic risk groups
| Cytogenetic prognostic subgroups | Cytogenetic abnormalities |
| Very good | -Y, del(11q) |
| Good | Normal, del(5q), del(12p), del(20q), double including del(5q) |
| Intermediate | del(7q), +8, +19, i(17q), any other single or double independent clones |
| Poor | -7, inv(3)/t(3q)/del(3q), double including -7/del(7q), Complex: 3 abnormalities |
| Very poor | Complex: >3 abnormalities |
How this calculator works:
Based on Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndromes. Greenberg PL, Tuechler H, Schanz J et al. 2012 Blood 120: 2454-2465.
The IPSS-R SCORE is calculated from the data shown in the following table:
IPSS-R Prognostic Score Values
| Prognostic variable | 0 | 0.5 | 1 | 1.5 | 2 | 3 | 4 |
| Cytogenetics | Very Good | Good | Intermediate | Poor | Very Poor | ||
| BM Blast % | <=2 | >2-<5% | 5-10% | >10% | |||
| Haemoglobin | =>100 | 80-<100 | <80 | ||||
| Platelets | =>100 | 50-<100 | <50 | ||||
| ANC | =>0.8 | <0.8 |
The IPSS-R category determines patient Survival (based on Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndromes. Greenberg PL, Tuechler H, Schanz J et al. 2012 Blood 120: 2454-2465.):
IPSS-R Prognostic Risk Categories/Scores and Clinical Outcomes
| RISK CATEGORY | RISK SCORE | SURVIVAL (median - years) |
25% AML evolution (median - years) |
| Very Low | <=1.5 | 8.8 | NR |
| Low | >1.5 - 3 | 5.3 | 10.8 |
| Intermediate | >3 - 4.5 | 3.0 | 3.2 |
| High | >4.5 - 6 | 1.6 | 1.4 |
| Very High | >6 | 0.8 | 0.73 |
The survival estimation calculation of risk (IPSS-RA) it is done base on the folowing formula:
result = score + ((age - 70) * (0.05 - (score * 0.005)));
result = result.toFixed(2); (2 decimal values)
